LSTM Team

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LSTM is an international postgraduate centre of excellence, devoted to research, education and training, and consultancy. A registered charity affiliated to the University of Liverpool, the School was founded in 1898, becoming the World's first institution devoted primarily to tropical health. It has extensive links with UN organisations, health ministries, universities, non-governmental organisations and research institutions worldwide and is an integral partner in numerous programmes that contribute to controlling diseases of poverty and development of more effective systems for health care. The School prides itself on its links with disease endemic countries and is committed to increasing such partnerships.  The Vector Group at LSTM has over 40 researchers with a major strength in mosquito biology and control and has recently moved into new laboratories with state of the art molecular facilities and extensive insectaries.  Our mission is to improve the control of arthropod disease vectors through a more complete understanding of their biology.

 

Consortium Leader: Professor Hilary Ranson

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Hilary Ranson has pioneered molecular studies into the mechanisms of insecticide resistance in malaria vectors. She has developed a number of tools to study insecticide resistance in field populations and used these to track resistance and determine its impact on malaria control.  

 

 

 

 

Researchers:

Dr Mark Paine

 

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Mark Paine is applying his skills in protein expression and biochemistry to understand the mechanisms by which mosquitoes are able to detoxify insecticides.  His group is studying enzyme-insecticide interactions to identify the molecular determinants of insecticide metabolism. 

Dr Gareth Lycett

 

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Gareth Lycett’s research group use functional genomic approaches to study Anopheles gambiae.  They use transgenic technology to develop new tools to understand gene regulation in mosquitoes and are leading the application of gene silencing technology to study insecticide resistance in mosquitoes. 

Dr Philip McCall

 

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Philip McCall studies the biology and behaviour of vectors to develop new or improved tools for vector control.  His studies in Africa, SE Asia and Latin America aim to design locally specific interventions that target vector populations with methods acceptable to affected communities. 

Mr Hyacinthe Toé

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AvecNet PhD Candidate 

Mr Edi Constant

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AvecNet PhD Candidate

Ms Josephine Parker

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AvecNet PhD Candidate 

Ms Kemi Tesfazghi

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AvecNet PhD Candidate

Dr Eve Worrall

 

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Eve Worrall has a background in economics and vector control. Eve manages the AvecNet project and is responsible for ensuring that all technical deliverables are achieved on time. She also manages the project finances and is a focal point for liaison with the EC. Eve also takes an active role in disseminating the project outputs aiming to ensure that they have the maximum impact on malaria policy.

Mrs Sharon Mullane

 

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Sharon Mullane has a background in international project administration and global logistics mobilisation. Sharon is currently responsible for managing the day to day administrative responsibilities of the project and project management office. In addition, Sharon provides support to all consortium members and PhD Students.

Dr Cristina Yunta Yanes   

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Cristina Yunta Yanes is a postdoctoral research assistant, involved in work package 3, with a background in molecular genetics and in protein expression, purification and characterization (physico-chemical and structural levels).  Currently, she is involved in characterize the metabolic profile of newly identified cytochrome p450 genes related to insecticide resistance in mosquitoes.  She has also been involved in the preparation of antigens to make antibodies against P450 and try to produce the samples for P450 x-ray crystallography.

Dr Amy Lynd

 

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Amy Lynd obtained a BSc in Genetics from the University of Liverpool in 1998 and an MSc in Sustainable Rural Development in the Tropics from Edinburgh University in 1999. She has recently completed a PhD at the Liverpool School of Tropical Medicine investigating the behavioural and evolutionary responses of Anopheles gambiae s.s. to insecticide treated bednets. She is currently working as a post-doctoral research assistant with Dr. Gareth Lycett in the Vector Group.

Mrs Patricia Pignatelli 

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Ms. Patricia Pignatelli: Research assistant, with a background in molecular genetics at LSTM for the past fourteen years.  Currently involved in identifying key transporter genes, from the ABC family, that are differentially expressed in resistant mosquitoes.  Could these transporter genes have a link or a role in the mechanism transporting the insecticide through the mosquito, especially across the blood brain barrier.  Pat has also been involved in the cloning of the newly identified cytochrome p450 genes and the expression of these enzymes.

Mr Nelson Grisales Alzate 

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Nelson Grisales Alzate is a MSc Student who has previously been working on the characterization of the insecticide resistance mechanisms of Aedes aegypti, main vector of Dengue fever, in Colombia. Nelson is currently studying the implementation of combination bednets in malaria vector control in Burkina Faso.