Translational Research

TRANSLATIONAL RESEARCH BANNER

AvecNet aims to ensure that all the experimental tasks are explicitly focussed on the translational pathway from the research environment to implementation and demonstrated sustainable effectiveness, and that the outputs of the project are effectively disseminated to all stakeholders.

Within the 10 work packages of the AvecNet project we have achieved progress in this area: 

 
1

 

Effectively communicating our scientific findings is critical to achieve translation. The AvecNet Project Management Office (PMO) is the focal point for communication between the partners and for external communication of our scientific outputs to the wider scientific community.

2

 

Identification and validation of genes responsible for insecticide resistance is being translated into new tools to screen for resistance in the field and into new methods for early stage screening of new insecticides.

New insecticides or formulation options selected for testing in the lab or field are subject to rigorous criteria for translation and sustainability, those which do not meet the criteria are not pursued.

3

 

Knowledge on mosquito behaviour generated via the non lethal mosquito tracking system will be directly used to inform the development of new mosquito control tools. AvecNet scientists have patented an innovative design for a bednet.

Filling the knowledge gaps on insecticide transport in vivo will inform the development of new formulations of insecticide better targeted to reach the insecticide target site.

4

 

Data from semi field and field trials of spatial repellents is being used to inform the development of target product profiles for novel spatial repellent products.

The optimal dose for treating sisal strips with transfluthrin to provide full protection against malaria vectors while at the same time minimizing the costs and potential risks of human exposure to the active ingredient is being assessed.

5

 

Interviews and focus group discussions with householders from different socio-economic settings have identified perceptions of responsibility for mosquito control, information which is of key importance when assessing the acceptability of new vector control tools to different stakeholder groups.

6

 

A scoping exercise of all vector control tools that met the inclusion criteria for the clinical trial was conducted at the end of Year One of the project, and the results reviewed by our External Technical Advisory Group, prior to the selection of the intervention to be trialled.

7

 

WP8 ensures that all activities remain focused on the translation of new knowledge into improved tools for malaria vector control, utilising the expertise provided by the ETAG and IVCC’s own ESAC committees, to inform the selection of products for field trials and the development of target product profiles.

9

Improving the rigour of field trials of new products, by building capacity in study design, development and implementation of standard operating protocols, and statistical analysis is helping accelerate the product development pipeline.

10

Stakeholders from community through local government to national and global level are being consulted to  assess roles and responsibilities in vector control and to map the policy making processes.