Work Package 6: Randomised control trial for assessing the protective efficacy of novel tools for malaria control

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WP6 Team


Work Package Leader: Professor Steve Lindsay. University of Durham






Plan and implement randomised phase III control trials

A clinical trial is underway in Banfora District, Burkina Faso to compare the efficacy of a new bed net (Olyset Duo) with two active ingredients, permethrin and pyriproxifen, with a standard Olyset pyrethroid bednet, in preventing malaria transmission. The study is a two arm cluster randomised wedge shape trial. All clusters have received new Olyset nets and step wise introduction of Olyset Duo nets has begun. The first clinical cross sectional survey has been completed and passive case detection and entomological surveillance are ongoing.  The trial will run for two malaria transmission seasons in 2014 and 2015.



Assessment of effectiveness of new tools

The efficacy of the intervention/s will be measured by two parameters;

1) through the analysis of malaria cases presenting at health facilities,

2) entomological indices of transmission




Publications & Outcomes 

S. N’Fale; M. Pinder; E. F.S. Tchicaya; A. B. Tiono; B. Faragher; H. Ranson and S. W. Lindsay. To assess whether addition of pyriproxyfen to long-lasting insecticidal mosquito nets increases their durability compared to standard long-lasting insecticidal mosquito nets: study protocol for a randomised controlled trial. Trials 2015, 16:195

S. W. Lindsay; A. B. Tiono; M. Pinder; S. N’Fale; B. Faragher; T. Smith; M. Silkey and H. Ranson. The AvecNet Trial to assess whether addition of pyriproxyfen, an insect juvenile hormone mimic, to long-lasting insecticidal mosquito nets provides additional protection against clinical malaria over current best practice in an area with pyrethroid-resistant vectors in rural Burkina Faso: study protocol for a randomised controlled trial. Trials 2015, 16:113

H. RansonFacing the resistance crisis in malaria control by developing and evaluating ‘resistance-breaking’ products. Outlooks in Pest Management. February 2014. p.33